Polycystic ovarian syndrme (PCOS) is marked in 30 to 40% by insulin resistance and hyperandrogenism. Myo-inositol increases insulin sensitivity, decreases hyperandrogenism and improves the menstrual cycle. Folic acid is said to promote regular ovulation and increased progesterone levels in the second half of the menstrual cycle. This may support fertility. Chaste Tree Extract is effective for premenstrual syndrome (PMS).Chaste Tree Extract decreases some symptoms of PMS, especially breast pain or tenderness, moodiness, anxiety, anger, and headache.